Publikationen – Original- und Übersichtsarbeiten (Wedel)


  • Bayer A, Heinze T, Alkatout I, Osmonov D, Stelzner S, Wedel T. Embryological Development and Topographic Anatomy of Pelvic Compartments-Surgical Relevance for Pelvic Lymphonodectomy. J Clin Med. 2021 Feb 11;10
  • Wedel T, Heinze T, Möller T, van Hillegersberg R, Bleys RLAW, Weijs TJ, van der Sluis PC, Grimminger PP, Sallum RA, Becker T, Egberts JH. Surgical anatomy of the upper esophagus related to robot-assisted cervical esophagectomy. Dis Esophagus. 2021 Jan 16
  • Alkatout I, Günther V, Brügge S, Ackermann J, Krüger M, Bauerschlag D, Maass N, Lippross S, Cascorbi I, Egberts JH, Becker T, Osmonov D, Jünemann KP, Wedel T. Involvement of medical students in a surgery congress: impact on learning motivation, decision-making for a career in surgery, and educational curriculum. Wien Med Wochenschr. 2021 Jan 14.
  • Cossais F, Schaeffer E, Heinzel S, Zimmermann J, Niesler B, Röth R, Rappold G, Scharf A, Zorenkov D, Lange C, Barrenschee M, Margraf NG, Ellrichmann M, Berg D, Böttner M, Wedel T. Expression Profiling of Rectal Biopsies Suggests Altered Enteric Neuropathological Traits in Parkinson's Disease Patients. J Parkinsons Dis. 2021;11(1):171-176
  • Stelzner S, Heinze T, Nikolouzakis TK, Torge Mees S, Witzigmann H, Wedel T. Perirectal Fascial Anatomy: New Insights Into an Old Problem. Dis Colon Rectum. 2021 Jan;64(1):91-102
  • Ackermann J, Wedel T, Hagedorn H, Maass N, Mettler L, Heinze T, Alkatout I. Establishment and evaluation of a training course in advanced laparoscopic surgery based on human body donors embalmed by ethanol-glycerol-lysoformin fixation. Surg Endosc. 2021 Mar;35(3):1385-1394


  • Pretterklieber B, Hader M, Hammer N, Pryymachuk G, Pröls F, Vielmuth F, Barnerßoi M, Cotofana S, Custozzo A, Weyers I, Wedel T, Arnold P, Rahner C, Müller-Gerbl M, Pretterklieber ML. When and why was the phrenicoabdominal branch of the left phrenic nerve placed into the esophageal hiatus in German textbooks of anatomy? An anatomical study on 400 specimens reevaluating its course through the diaphragm. Ann Anat. 2020; 227
  • Ackermann J, Wedel T, Holthaus B, Bojahr B, Hackethal A, Brucker S, Biebl M, Westermann M, Günther V, Krüger M, Maass N, Mettler L, Peters G, Alkatout I. Didactic Benefits of Surgery on Body Donors during Live Surgery Events in Minimally Invasive Surgery. J Clin Med. 2020 Sep 9;9(9):2912
  • Wong YL, Hummitzsch L, Lautenschläger I, Zitta K, Wedel T, Cossais F, Schafmayer C, Becker T, Berndt R, Gruenewald M, Weiler N, Steinfath M, Albrecht M. Putative function of goblet cells as epithelial sealing in ischaemia/reperfusion-induced intestinal barrier dysfunction. Gut. 2020 Oct;69(10):1888-1890


  • Wedel T, Ackermann J, Hagedorn H, Mettler L, Maass N, Alkatout I. Educational training in laparoscopic gynecological surgery based on ethanol-glycerol-lysoformin-preserved body donors. Ann Anat. 2019;221:157-164
  • Schafmayer C, Harrison JW, Buch S, Lange C, Reichert MC, Hofer P, Cossais F, Kupcinskas J, von Schönfels W, Schniewind B, Kruis W, Tepel J, Zobel M, Rosendahl J, Jacobi T, Walther-Berends A, Schroeder M, Vogel I, Sergeev P, Bödeker H, Hinrichsen H, Volk A, Erk JU, Burmeister G, Hendricks A, Hinz S, Wolff S, Böttner M, Wood AR, Tyrrell J, Beaumont RN, Langheinrich M, Kucharzik T, Brezina S, Huber-Schönauer U, Pietsch L, Noack LS, Brosch M, Herrmann A, Thangapandi RV, Schimming HW, Zeissig S, Palm S, Focke G, Andreasson A, Schmidt PT, Weitz J, Krawczak M, Völzke H, Leeb G, Michl P, Lieb W, Grützmann R, Franke A, Lammert F, Becker T, Kupcinskas L, D’Amato M, Wedel T, Datz C, Gsur A, Weedon MN, Hampe J: Genome-wide association analysis of diverticular disease points towards neuromuscular, connective tissue and epithelial pathomechanisms. Gut. 2019;68:854-865
  • Cossais F, Lange C, Barrenschee M, Möding M, Ebsen M, Vogel I, Böttner M, Wedel T. Altered enteric expression of the homeobox transcription factor Phox2b in patients with diverticular disease. United European Gastroenterol J. 2019 Apr;7(3):349-357
  • Hummitzsch L, Zitta K, Berndt R, Wong YL, Rusch R, Hess K, Wedel T, Gruenewald M, Cremer J, Steinfath M, Albrecht M. Remote ischemic preconditioning attenuates intestinal mucosal damage: insight from a rat model of ischemia-reperfusion injury. J Transl Med. 2019 Apr 29;17(1)
  • Fritscher-Ravens A, Pflaum T, Mösinger M, Ruchay Z, Röcken C, Milla PJ, Das M, Böttner M, Wedel T, Schuppan D. Many Patients With Irritable Bowel Syndrome Have Atypical Food Allergies Not Associated With Immunoglobulin E. Gastroenterology. 2019 Jul;157(1):109-118
  • Cossais F, Leuschner S, Barrenschee M, Lange C, Ebsen M, Vogel I, Böttner M, Wedel T. Persistent Increased Enteric Glial Expression of S100β is Associated With Low-grade Inflammation in Patients With Diverticular Disease. J Clin Gastroenterol. 2019 Jul;53(6):449-456
  • Barrenschee M, Cossais F, Böttner M, Egberts JH, Becker T, Wedel T: Impaired expression of Neuregulin 1 and nicotinic acetylcholine receptor beta 4 subunit in diverticular disease. Frontiers in Cellular Neuroscience 2019
  • Anapolski M, Alkatout I, Wedel T, Panayotopoulos D, Soltesz S, Schiermeier S, Papathemelis T, Noé GK. Laparoscopic approaches to the retropubic space: three alternatives with anatomical considerations. Minim Invasive Ther Allied Technol 2019; 23:1-9


  • Alkatout I, Holthaus B, Wedel T, Mettler L, Ackermann J, Maass N: Entwicklung der minimalinvasiven Chirurgie in der Gynäkologie und Überwindung assoziativer Herausforderungen. Gynäkologe 2018
  • Strey CW, Wullstein C, Adamina M, Agha A, Aselmann H, Becker T, Grützmann R, Kneist W, Maak M, Mann B, Moesta KT, Runkel N, Schafmayer C, Türler A, Wedel T, Benz S. Laparoscopic right hemicolectomy with CME: standardization using the "critical view" concept. Surg Endosc. 2018;32:5021-5030
  • Franke J, Homeier A, Metz L, Wedel T, Alt V, Spät S, Hohendorff B, Schnettler R. Infrapatellar vs. suprapatellar approach to obtain an optimal insertion angle for intramedullary nailing of tibial fractures. Eur J Trauma Emerg Surg 2018;44:927-938.
  • Wedel T, Stelzner S: Chirurgische Anatomie zur kompletten mesokolischen Exzision. Coloproctology 2018;40:15–23
  • Jongen J, Kahlke V, Wedel T. Anatomically Incorrect. Dtsch Arztebl Int. 2018;115:112
  • Alkatout I, Wedel T, Maass N: Kombinierte Therapie der Endometriose: Radikal und schonend zugleich. Akt Uro 2018;49: 60–72
  • Rosenbaum C, Böttner M, Wedel T, Metzger M. Laser-Capture Microdissection for Layer-Specific Analysis of Enteric Ganglia. Methods Mol Biol. 2018;1723:361-369
  • Stelzner S, Böttner M, Kupsch J, Kneist W, Quirke P, West NP, Witzigmann H, Wedel T. Internal anal sphincter nerves - a macroanatomical and microscopic description of the extrinsic autonomic nerve supply of the internal anal sphincter. Colorectal Dis. 2018;20


  • Kneist W, Stelzner S, F. Aigner, Fürst A, Wedel T. Urethral injury in body donor TaTME training. Coloproctology 2017;39:179-183
  • Kaiser B, Böttner M, Wedel T, Brunner RM, Goldammer T, Lesko S, Gäbel G, Gleich A, Pfannkuche H. Establishment and Characterization of an SV40 Large T Antigen-Transduced Porcine Colonic Epithelial Cell Line. Cells Tissues Organs. 2017;203:267-286
  • Wunsch M, Jabari S, Voussen B, Enders M, Srinivasan S, Cossais F, Wedel T, Boettner M, Schwarz A, Weyer L, Göcer O, Schroeter M, Maeurer M, Woenckhaus M, Pollok K, Radbruch H, Klotz L, Scholz CJ, Nickel J, Friebe A, Addicks K, Ergün S, Lehmann PV, Kuerten S. The enteric nervous system is a potential autoimmune target in multiple sclerosis. Acta Neuropathol 2017;134:281-295
  • Cotofana S, Pretterklieber B, Lucius R, Frank K, Haas M, Schenck TL, Gleiser C, Weyers I, Wedel T, Pretterklieber M. Distribution Pattern of the Superior and Inferior Labial Arteries: Impact for Safe Upper and Lower Lip Augmentation Procedures. Plast Reconstr Surg 2017;139:1075-1082
  • Barrenschee M, Wedel T, Lange C, Hohmeier I, Cossais F, Ebsen M, Vogel I, Böttner M. No neuronal loss, but alterations of the GDNF system in asymptomatic diverticulosis. PLoS One 2017;12
  • Barrenschee M, Zorenkov D, Böttner M, Lange C, Cossais F, Scharf AB, Deuschl G, Schneider SA, Ellrichmann M, Fritscher-Ravens A, Wedel T. Distinct pattern of enteric phospho-alpha-synuclein aggregates and gene expression profiles in patients with Parkinson's disease. Acta Neuropathol Commun 2017;5
  • Kneist K, Stelzner S, Hanke LI, Wedel T: Inferior rectal plexus is no longer isolated in noman’s land. An encouraging outlook with TaTME. Coloproctology 2017;39:85-87


  • Eckhoff K, Wedel T, Both M, Bas K, Maass N, Alkatout I. Spontaneous rectus sheath hematoma in pregnancy and a systematic anatomical workup of rectus sheath hematoma: a case report. J Med Case Rep 2016;19:292
  • Stelzner S, Hohenberger W, Weber K, West NP, Witzigmann H, Wedel T. Anatomy of the transverse colon revisited with respect to complete mesocolic excision and possible pathways of aberrant lymphatic tumor spread. Int J Colorectal Dis 2016;31:377-84
  • Schneider SA, Böttner M, Alexoudi A, Zorenkov D, Deuschl G, Wedel T: Can we use peripheral tissue biopsies to diagnose Parkinson´s disease? A review of the literature.. Eur J Neurol 2016;23:247-61


  • Wedel T, Barrenschee M, Lange C, Cossais F, Böttner M. Morphologic Basis for Developing Diverticular Disease, Diverticulitis, and Diverticular Bleeding. Viszeralmedizin. 2015;31:76-82
  • Barrenschee M, Lange C, Cossais F, Egberts JH, Becker T, Wedel T, Böttner M. Expression and function of Neuregulin 1 and its signaling system ERBB2/3 in the enteric nervous system. Front Cell Neurosci. 2015;9:360
  • Borggrefe J, Bolte H, Worms W, Mahlke L, Seekamp A, Menzdorf L, Varoga D, Müller M, Weuster M, Zorenkov D, Wedel T, Lippross S. Comparison of intraoperative flat panel imaging and postoperative plain radiography for the detection of intraarticular screw displacement in volar distal radius plate ostheosynthesis. Orthop Traumatol Surg Res. 2015;101:913-7
  • Shekarriz H, Eigenwald J, Shekarriz B, Upadhyay J, Shekarriz J, Zoubie D, Wedel T, Wittenburg H. Anastomotic leak in colorectal surgery: are 75 % preventable? Int J Colorectal Dis. 2015;30:1525-31
  • Wedel T, Barrenschee M, Cossais F, Lange C, Böttner M. Diverticular disease - new insights into pathogenesis. Dtsch Med Wochenschr. 2015;140:1347-52
  • Heneweer C, Siggelkow M, Helle M, Petzina R, Wulff A, Schaefer JP, Berndt R, Rusch R, Wedel T, Klaws G, Müller-Gerbl M, Röcken C, Jansen O, Lutter G, Cremer J, Groß J: Laser scoop desobliteration: a method for minimally invasive remote recanalization of chronically occluded superficial femoral arteries. J Biomed Opt 2015;20:25005
  • Alkatout I, Egberts JH, Mettler L, Doniec M, Wedel T, Jünemann KP, Becker T, Jonat W, Schollmeyer T: Interdisciplinary Diagnosis and Treatment of Deep Infiltrating Endometriosis. Zentralbl Chir 2015;[Epub ahead of print]
  • Böttner M, Fricke T, Müller M, Barrenschee M, Deuschl G, Schneider SA, Egberts JH, Becker T, Fritscher-Ravens A, Ellrichmann M, Schulz-Schaeffer WJ, Wedel T: Alpha-synuclein is associated with the synaptic vesicle apparatus in the human and rat enteric nervous system. Brain Res 2015;21:51-9
  • Barrenschee M, Böttner M, Harde J, Lange C, Cossais F, Ebsen M, Vogel I, Wedel T: SNAP 25 is abundantly expressed in enteric neuronal networks and upregulated by the neurotrophic factor GDNF. Histochem Cell Biol 2015;143:611-23


  • Marczynski-Bühlow M, Gro J, Berndt R, Röcken C, Wedel T, Böttner M, Cremer J, Lutter G, Petzina R: Comparison of different resection tools for human calcified aortic valves. Innovations 2014;9:312-6
  • Leifeld L, Germer CT, Böhm S, Dumoulin FL, Häuser W, Kreis M, Labenz J, Lembcke B, Post S, Reinshagen M, Ritz JP, Sauerbruch T, Wedel T, von Rahden B, Kruis W, Kruis W, Germer W: S2k-Leitlinie Divertikelkrankheit/Divertikulitis. Z Gastroenterol 2014;52:663-710
  • Böttner M, Ghorbani P, Harde J, Barrenschee M, Hellwig I, Vogel I, Ebsen M, Förster E, Wedel T: Expression and regulation of reelin and its receptors in the enteric nervous system. Mol Cell Neurosci 2014;61:23-33
  • Wedel T, Böttner M. Anatomie und Pathogenese der Divertikelkrankheit. Chirurg 2014;85:281-8
  • Hellwig I, Böttner M, Barrenschee M, Harde J, Egberts JH, Becker T, Wedel T: Alterations of the enteric smooth musculature in diverticular disease. J Gastroenterol 2014;49:1241-52


  • Böttner M, Harde J, Barrenschee M, Hellwig I, Vogel I, Ebsen M, Wedel T. GDNF induces synaptic vesicle markers in enteric neurons. Neurosci Res 2013;77:128-36
  • Andresen V, Enck P, Frieling T, Herold A, Ilgenstein P, Jesse N, Karaus M, Kasparek M, Keller J, Kuhlbusch-Zicklam R, Krammer H, Kreis M, Layer P, Madisch A, Matthes H, Mönnikes H, Müller-Lissner S, Preiss J, Sailer M, Schemann M, Schwille-Kiuntke J, Voderholzer W, van der Voort I, Wedel T, Pehl C. S2k-Leitlinie Chronische Obstipation: Definition, Pathophysiologie, Diagnostik und Therapie. Z Gastroenterol. 2013;51:651-72
  • Barrenschee M, Böttner M, Hellwig I, Jonas H, Egberts JH, Becker T, Wedel T. Site-specific gene expression and localization of the growth factor ligand receptors RET, GFRa1 and GFRa2 in the human adult colon. Cell Tissue Res 2013;354:371-80
  • Böttner M, Barrenschee M, Hellwig I, Harde J, Egberts J-H., Becker T, Zorenkov D, Schäfer K-H, Wedel T. The GDNF system is altered in diverticular disease – implications for pathogenesis. PLos One 2013;8:e66290
  • Hagl C, Schäfer KH, Hellwig I, Barrenschee M, Harde J, Holtmann M, Porschek S, Egberts JH, Becker T, Wedel T, Böttner M. Expression and function of the Transforming Growth Factor-b system in the human and rat enteric nervous system. Neurogastroenterol Motil 2013;25:601-e464
  • Noth R, Häsler R, Stüber E, Ellrichmann M, Schäfer H, Geismann C, Hampe J, Bewig B, Wedel T, Böttner M, Schreiber S, Rosenstiel P, Arlt A. Oral glutamine supplementation improves intestinal permeability dysfunction in a murine acute graft versus host disease model. Am J Physiol Gastrointest Liver Physiol 2013;304:G646-54
  • Elessawy M, Schollmeyer T, Rajabi A, Wedel T, Mettler L, Jonat W, Alkatout I. Intraoperative splenic injury as complication of excision of uterine myoma. Case Study and Case Report 2013;3:55-60
  • Fritscher-Ravens A, Milla P, Ellrichmann M, Hellwig I, Böttner M, Hadeler KG, Wedel T. A novel endoscopic prototype device for gastric full-thickness biopsy for the histopathological diagnosis of GI neuromuscular pathology: in vivo porcine long-term survival study (with videos). Gastrointest Endosc 2013;77:262-71
  • Böttner M, Barrenschee M, Hellwig I, Harde J, Egberts JH, Becker T, Zorenkov D, Wedel T. The enteric serotonergic system is altered in patients with diverticular disease. Gut 2013;62:1753-62


  • Böttner M, Zorenkov D, Hellwig I, Barrenschee M, Harde J, Fricke T, Deuschl G, Egberts JH, Becker T, Fritscher-Ravens A, Arlt A, Wedel T. Expression pattern and localization of alpha-synuclein in the human enteric nervous system. Neurobiol Dis 2012;48:474-80
  • Böttner M, Wedel T. Abnormalities of neuromuscular anatomy in diverticular disease. Dig Dis 2012;30:19-23
  • Wedel T, Barrenschee M, Hellwig I, Harde J, Böttner M. Pathogenesis of diverticulosis and diverticular disease of the colon. Viszeralmedizin 2012;28:164-70
  • Kayser O, Osmonov D, Harde J, Girolami G, Wedel T, Schäfer P. Less invasive causal treatment of ejaculatory duct obstruction by balloon dilation: a case report, literature review and suggestion of a CT- or MRI-guided intervention. GMS German Medical Science 2012;10:1-8


  • Zorenkov D, Otto S, Böttner B, Hedderich J, Vollrath O, Peter JP, Buhr H, Wedel T. Morphological alterations of the enteric nervous system in young male patients with rectal prolapse. Int J Colorectal Dis 2011;26:1483-91
  • Van Landeghem L, Chevalier J, Mahé MM, Wedel T, Urvil P, Derkinderen P, Savidge TC, Neunlist M. Enteric glia promotes intestinal mucosal healing via activation of focal adhesion kinase and release of ProEGF. Am J Physiol Gastrointest Liver Physiol 2011;300:G976-87  
  • Stelzner S, Holm T, Moran BJ, Heald RJ, Witzigmann H, Zorenkov D, Wedel T. Deep pelvic anatomy revisited for a description of crucial steps in extralevator abdominoperineal excision for rectal cancer. Dis Colon Rectum 2011;54:947-57
  • Keller J, Wedel T, Seidl H, Kreis ME, Andresen V, Preiß JC, Layer P, van der Voort I. S3-Leitlinie der Deutschen Gesellschaft für Verdauungs- und Stoffwechselkrankheiten (DGVS) und der Deutschen Gesellschaft für Neurogastroenterologie und Motilität (DGNM) zu Definition, Pathophysiologie, Diagnostik und Therapie intestinaler Motilitätsstörungen. Z Gastroenterol 2011;49:374-390
  • Petto C, Lesko S, Gäbel G, Böttner M, Wedel T, Kacza J, Pfannkuche H. Establishment and characterisation of porcine colonic epithelial cells grown in primary culture. Cells Tissue Organs 2011;194:457-68
  • Knowles CH, Veress B, Kapur RP, Wedel T, Farrugia G, Vanderwinden JM, Geboes K, Smith VV, Martin JE, Lindberg G, Milla PJ, De Giorgio R. Quantitation of cellular components of the enteric nervous system in the normal human gastrointestinal tract. Report on behalf of the Gastro 2009 International Working Group. Neurogastroentrol Motil 2011;23:115-24
  • Pahl R, Brunke G, Steubesand N, Schubert S, Böttner M, Wedel T, Jürgensen C, Hampe J, Schäfer H, Zeissig S, Schreiber S, Rosenstiel P, Reiss K, Arlt A. IL-1ß and ADAM17 are central regulators of ß-defensin expression in Candida esophagitis. Am J Physiol Gastrointest Liver Physiol 2011;300:G547-53


  • Knowles CH, De Giorgio R, Kapur RP, Bruder E, Farrugia G, Geboes K, Lindberg G, Martin JE, Meier-Ruge WA, Milla PJ, Smith VV, Vandervinden JM, Veress B, Wedel T. The London classification of gastrointestinal neuromuscular pathology (GINMP): report on behalf of the Gastro 2009 International Working Group. Gut 2010;59:882-7
  • Wedel T, Büsing V, Heinrichs G, Nohroudi K, Bruch HP, Roblick U, Böttner M. Diverticular disease is associated with an enteric neuropathy as revealed by morphometric analysis. Neurogastroenterol Motil 2010;22:407-14
    Kommentar in: Research Highlights, Nature Gastroenterology and Hepatology, May 2010;7:240
  • Böttner M, Bär F, von Koschitzky H, Tafazzoli K, Roblick UJ, Bruch HP, Wedel T. Laser microdissection as a new tool to investigate site-specific gene expression in enteric ganglia of the human intestine. Neurogastroenterol Motil 2010;22:168-72  
  • Böttner M, Leonhardt S, Wuttke W, Wedel T, Jarry H. Expression of estrogen receptors in the hypothalamo-pituitary-ovarian axis in middle-aged rats after re-instatement of estrus cyclicity. Biogerontol 2010;11:75-85


  • Jongen J, Kahl I, Pflug A, Wedel T, Volker K. Perioperative ambulante Schmerztherapie in der Proktologie. Ambulante Chirurgie 2009;6:29-32
  • Wedel T. Anatomische Grundlagen für die Kontinenz. DCCV 2009;96:10-14
  • Teixeira AF, Kühnel W, Vives P, Wedel T. Functional morphology of unguiculiform papillae of the reticular groove in the ruminant stomach. Ann Anat 2009;191:469-76.
  • Knowles CH, De Giorgio R, Kapur RP, Bruder E, Farrugia G, Geboes K, Gershon MD, Hutson J, Lindberg G, Martin JE, Meier-Ruge WA, Milla PJ, Smith VV, Vanderwinden JM, Veress B, Wedel T. Gastrointestinal neuromuscular pathology: guidelines for histological techniques and reporting on behalf of the Gastro 2009 International Working Group. Acta Neuropathol 2009;118:271-301
  • Neunlist M, Coron E, Flamant M, Aubert P, Wedel T, Pedron T, Letessier E, Galmiche JP, Sansonetti PJ. Characterisation of early mucosal and neuronal lesions following Shigella flexneri infection in human colon. PLoS ONE 2009;4(3):e4713
  • Bär F, von Koschitzky H, Roblick U, Bruch HP, Schulze L, Sonnenborn U, Böttner M, Wedel T. Cell-free supernatants of Escherichia coli Nissle 1917 (EcN) modulate human colonic motility – evidence from an in-vitro organ bath study (2009). Neurogastroenterol Motil 2009;21:559-66
  • Spanholtz T, Maichle A, Niedworok C, Stoeckelhuber BM, Krüger S, Wedel T, Aach T, Middeler G, Hellwig-Bürgel T, Bader A, Krengel S, Müller OJ, Franz WM, Lindenmaier W, Machens HG. Timing and targeting of cell-based VEGF(165) gene expression in ischemic tissue. J Surg Res 2009;151:153-62
  • Aigner F, Gruber H, Conrad F, Eder J, Wedel T, Zelger B, Engelhardt V, Lametschwandtner A, Wienert V, Böhler U, Margreiter R, Fritsch H. Revised morphology and hemodynamics of the anorectal vascular plexus: Impact on the course of hemorrhoidal disease. Int J Colorectal Dis 2009;24:105-13


  • Jacobsen HC, Hakim SG, Lauer I, Dendorfer A, Wedel T, Sieg P. Long-term results of autologous submandibular gland transfer for the surgical treatment of severe keratoconjunctivitis sicca. J Craniomaxillofac Surg 2008;36:227-233
  • Harloff S, Hartwig D, Kasper K, Wedel T, Müller M, Geerling G. Epitheliotrophic Capacity of Serum Eye Drops from Healthy Donors versus Serum from Immunosuppressed Patients with Rheumatoid Arthritis. Klin Monatsbl Augenheilkd 2008;225:200–206
  • Farke S, Paech A, Duchrow M, Bethge T, Wedel T, Lindner B, Roblick UJ, Bruch HP, Broll R. Re-Sterilization of Surgical Polypropylene Meshes: Should it be Done? Research Journal of Medical Science 2008;2:7-12


  • Wedel T. Functional Anatomy – Prerequisite for the understanding of defecation disorders. Chir Gastroenterol 2007;23:220-227
  • Wedel T, Böttner M, Krammer HJ. The enteric nervous system and interstitial cells of Cajal. Changes in chronic constipation in adults. Pathologe 2007;28:143-148
  • Schrader S, Wedel T, Kremling C, Laqua H, Geerling G. Amniotic membrane as a carrier for lacrimal gland acinar cells. Graefes Arch Clin Exp Ophthalmol 2007;245:1699-704
  • Hernando-Harder AC, Franke A, Wedel T, Bottner M, Krammer HJ, Singer MV, Harder H. Intestinal Gas Retention in Patients with Idiopathic Slow-Transit Constipation. Dig Dis Sci 2007;52:2667-75
  • Beutel J, Schroder C, von Hof K, Rades D, Kosmehl H, Wedel T, Sieg P, Geerling G, Hakim S. Pharmacological prevention of radiation-induced dry eye – An experimental study in a rabbit model. Graefes Arch Clin Exp Ophthalmol 2007;245:1347-55
  • Neunlist M, Aubert P, Bonnaud S, van Landeghem L, Coron E, Wedel T, Naveilhan P, Ruhl A, Lardeux B, Savidge T, Paris F, Galmiche JP. Enteric glia inhibits intestinal epithelial cell proliferation partly through a TGF-ß1-dependent pathway. Am J Physiol Gastrointest Liver Physiol 2007;292:231-241
  • Kohl M, Wedel T, Entenmann A, Stuttmann J, Bendiks M, Loff S, Koster S, Ortfeld S, Bos I. Influence of different intravenous lipid emulsions on hepatobiliary dysfunction in a rabbit model. J Pediatr Gastroenterol Nutr 2007;44:237-44


  • Kruse C, Kajahn J, Petschnik AE, Maass A, Klink E, Rapoport DH, Wedel T. Adult pancreatic stem/progenitor cells spontaneously differentiate in vitro into multiple cell lineages and form teratoma-like structures. Ann Anat 2006;188:503-517
  • Schrader S, Wedel T, Moll R, Geerling G. Combination of serum eye drops with hydrogel bandage contact lenses in the treatment of persistent epithelial defects. Graefes Arch Clin Exp Ophthalmol 2006;244:1345-1349
  • Wedel T. Der Beckenboden: Anatomische Grundlagen. Viszeralchirurgie 2006;41:153-162
  • Wedel T, van Eys G, Glénisson W, Waltregny D, Vanderwinden JM. Novel smooth muscle markers reveal abnormalities of the intestinal musculature in severe colorectal motility disorders. Neurogastroenterol Motil 2006;18:526-538
  • Liu L, Hartwig D, Harloff S, Herminghaus P, Wedel T, Geerling G. Corneal epitheliotrophic capacity of three different blood-derived preparations. Invest Ophtamol Vis Sci 2006;47:2438-2444
  • Nishino T, Wedel T, Schmitt O, Bühlmeyer K, Schönfelder M, Hirtreiter C, Schulz T, Kühnel W, Michna H. The xenoestrogen bisphenol A in the Hershberger assay: androgen receptor regulation and morphometrical reactions indicate no major effects. J Steroid Biochem Mol Biol 2006;98:155-163
  • Hakim S, Schroder C, Geerling G, Lauer I, Wedel T, Kosmehl H, Driemel O, Jacobsen HC, Trenkle T, Hermes D, Sieg. Early and late immunohistochemical and ultrastructural changes associated with functional impairment of the lacrimal gland following external beam radiation. Int J Exp Pathol 2006;87:65-71


  • Hakim S, Kosmehl H, Lauer I, Nadrowitz R, Wedel T, Sieg P A. Comparative study on the protection profile of lidocaine, amifostine and pilocarpine on the parotid gland during radiotherapy. Cancer Res 2005;65:10486-10493
  • Niessen P, Rensen S, van Deursen J, De Man J, De Laet A, Vanderwinden JM, Wedel T, Baker D, Doevendans P, Hofker M, Gijbels M, van Eys G Smoothelin-A. Is essential for functional intestinal smooth muscle contractility in mice. Gastroenterology 2005;129:1592-1601
  • de Lorijn F, de Jonge WJ, Wedel T, Vanderwinden JM, Benninga MA, Boeckxstaens GE. Interstitial cells of Cajal are involved in the afferent limb of the rectoanal inhibitory reflex. Gut 2005;54:1107-13
  • Tafazzoli K, Soost K, Wessel L, Wedel T. Topographic pecularities of the submucous plexus in the human anorectum – consequences for histopathologic evaluation of rectal biopsies. Eur J Pediatr Surg 2005;15:159-63
  • Liu L, Hartwig D, Harloff S, Herminghaus P, Wedel T, Geerling G. An optimised protocol for the production of autologous serum eyedrops. Graefes Arch Clin Exp Ophthalmol 2005;243:706-714
  • Wedel T Obstipation. Coloproctology 2005;27:204-208
  • Sayk F, Bos I, Schubert U, Wedel T, Sievers HH. Histopathologic findings in a novel decellularized pulmonary homograft: an autopsy study. Ann Thorac Surg 2005;79:1755-8
  • Tiedemann K, Sasaki T, Gustafsson E, Göhring W, Bätge B, Notbohm H, Wedel T, Schlötzer-Schrehardt U, Reinhardt DP. Microfibrils at basement membrane zones interact with perlecan via fibrillin-1. J Biol Chem 2005;25:11404-12
  • Hartwig D, Herminghaus D, Wedel T, Schlenke P, Geerling G. Topical treatment of ocular surface defects: Comparison of the epitheliotrophic capacity of fresh frozen plasma and serum on corneal epithelial cells in an in-vitro cell culture model. Transfusion Med 2005;15:107-113
  • Most P, Boerries M, Eicher C, Schweda C, Wedel T, Söllner S, Katus HA, Remppis A, Aebi U, Koch WJ, Schoenenberger CA. Distinct subcellular location of the Ca2+-binding protein S100A1 differentially modulates Ca2+-cycling in ventricular rat cardiomyocytes. J Cell Science 2005;118:421-31


  • Hartwig D, Harloff S, Liu L, Schlenke P, Wedel T, Geerling G. Epitheliotrophic capacity of a growth factor preparation produced from platelet concentrates on corneal epithelial cells: A potential agent for the treatment of ocular surface defects? Transfusion 2004;44:1724-31
  • Birth M, Wedel T, Hildebrand P, Bruch HP, Kruse C. Isolation culture and characterization of adult pluripotent stem cells of pancreas. Chir Forum 2004;33:405-407
  • Herminghaus P, Hartwig D, Wedel T, Dibbelt L, Geerling G. Epitheliotrophic capacity of serum and plasma eyedrops. Influence of centrifugation. Ophtalmologe 2004;101:998-1005
  • Holland-Cunz S, Bainczyk S, Hagl C, Wink E., Wedel T, Back W, Schäfer KH. Three dimensional co-culture model of enterocytes and primary enteric neuronal tissue. Pediatr Surg Internat 2004;20:233-7
  • Nishino T, Wedel T, Schmitt O, Bühlmeyer K, Schönfelder M, Hirtreiter C, Schulz T, Kühnel W, Michna H. Androgen-dependent morphology of prostate and seminal vesicles in the Hershberger Assay: Evaluation of immunohistochemical and morphometric parameters. Ann Anat 2004;186:247–253
  • Schlieger F, Wedel T, Krammer H. Annual meeting of the German Society for Neuro-gastroenterology and Motility. Z Gastroenterol 2004;42:565-8
  • Bruch HP, Schwandner O, Krammer HJ, Söllner S, Wedel T. Ursachen und Therapie des Megakolons beim Erwachsenen. Chir Praxis 2004;62:605-617
  • Kruse C, Birth M, Rohwedel J, Assmuth K, Göpel A, Wedel T. Pluripotency of adult stem cells derived from human and rat pancreas. Appl Phys A 2004


  • Wedel T, Tafazzoli K, Söllner S, Krammer HJ, Holschneider AM. Mitochondrial myopathy (complex I deficiency) associated with chronic intestinal pseudoobstruction. Eur J Pediatr Surg 2003;13:201-205
  • Holland-Cunz S, Krammer HJ, Süss A, Tafazzoli K, Wedel T. Molecular genetics of colorectal motility disorders. Eur J Pediatr Surg 2003;13:146-151


  • Wedel T, Spiegler J, Söllner S, Roblick UJ, Schiedeck THK, Bruch HP, Krammer HJ. Interstitial cells of Cajal and the enteric nervous system are concomitantly altered in patients with slow-transit constipation and megacolon. Gastroenterology 2002;123:1459-1467
  • Hakim S, Kossmehll H, Lauer I, Nadrowitz R, Wedel T Sieg P. The role of myoepithelial cells in the short-term radiogenic impairment of salivary glands. An immunohistochemical, ultrastructural and scintigraphic study. Anticancer Res 2002;22:4121-4128
  • Von Boyen GBT, Krammer HJ, Dembowski C, Ehrenreich H, Wedel T. Abnormalities of the enteric nervous system in heterozygous endothelin B-receptor deficient (spotting lethal) rats resembling intestinal neuronal dysplasia. Gut 2002;51:414-419
  • Wedel T, Roblick UJ, Ott V, Eggers R, Schiedeck THK, Krammer HJ, Bruch HP. Oligoneuronal hypoganglionosis in patients with idiopathic slow transit constipation. Dis Colon Rectum 2002;45:54-62
  • Krammer HJ, Süss A, Singer MV, Wedel T. Neurogastroenterology – From the Basics to the Clinics. R J Gastroenterology 2002;11:313-319


  • Teixera AF, Krammer HJ, Kühnel W, Wedel T. Structural organisation of the enteric nervous system in the cattle esophagus revealed by wholemount immunohistochemistry. It J Anat Embryol 2001;106:313-321


  • Wedel T, Roblick UJ, Schiedeck THK, Bruch HP Reusche E. Erworbene Hypoganglionose als Folge einer enterischen Ganglionitis. Focus MUL 2000;17:246-248
  • Wedel T, Spiegler J, Ott V, Kühnel W, Sigge W, Reusche E, Krammer HJ. Intestinale Innervationsstörungen bei chronischer Obstipation. Focus MUL 2000;17:233-240
  • Wedel T. Mögliche Ursachen der chronischen Obstipation. Zentralbl Chir 2000;125:564-566


  • Leffler A, Wedel T, Busch LC. Congenital colonic hypoganglionosis in murine trisomy 16 - a model for Down´s syndrome. Eur J Pediatr Surg 1999;9:381-388
  • Wedel T, Roblick UJ, Quoß J, Schiedeck THK, Bruch HP, Krammer HJ. Intestinale Innervationsstörungen: Anatomische Grundlagen und Diagnostik. Coloproctology 1999;21:101-108
  • Wedel T, Eggers R, Gleiß J, Schiedeck THK, Bruch HP, Sigge W, Krammer HJ. Das enterische Nervensystem: Von der Anatomie zur Klinik. Focus MUL 1999;16:22-30
  • Wedel T, Roblick UJ, Schiedeck THK, Bruch HP, Krammer HJ. Ist die Divertikelkrankheit mit intestinalen Innervationsstörungen assoziiert? Viszeralchirurgie 1999;34:307-311
  • Wedel T, Roblick UJ, Gleiß J, Ott V, Eggers R, Kühnel W, Krammer HJ. Intestinale Innervationsstörungen als mögliche Ursache der chronischen Obstipation. Zentralbl Chir 1999;124:796-803
  • Wedel T, Roblick UJ, Gleiß J, Schiedeck THK, Bruch HP, Kühnel W, Krammer HJ. Organization of the enteric nervous system in the human colon demonstrated by wholemount immunohistochemistry with special reference to the submucous plexus. Ann Anat 1999;181:327-337
  • Michailova K, Wassilev W, Wedel T. Scanning and transmission electron microscopic study of visceral and parietal peritoneal regions in the rat. Ann Anat 1999;181:253-260
  • Entenmann A, Wedel T, Kolbert G, Bruch HP, Kühnel W. Morphologische Untersuchungen zur alloplastischen Deckung von Bauchwanddefekten. Focus MUL 1999;16:148-154
  • Entenmann A, Wedel T, Kolbert G, Kühnel W, Bruch HP. Scanning electron microscopy study including maceration techniques of an absorbable alloplastic implant designed for the reconstruction of ventral abdominal wall defects. Ann Anat 1999;181:237-245
  • Wedel T, Holschneider AM, Krammer HJ, Kühnel W. Ultrastructural features of nerve fascicles and basal lamina abnormalities in Hirschsprung´s disease. Eur J Ped Surg 1999;9:75-82


  • Krammer HJ, Wedel T, Brehmer A, Rathke R, Stach W, Singer M. The enteric nervous system - what can we learn from morphology? Z Gastroenterol 1997;(Suppl.2):5-13


  • Driessen M, Wetterling T, Wedel T, Preuss R. Secondary hyperparathyroidism and depression in chronic renal failure. Nephron 1995;70:334-339