Neurogastroenterology

 Fluorescence immunohistochemistry of PGP9.5 (red) and S100b (green) in human myenteric plexus of the colon Fluorescence immunohistochemistry of alpha-Synuclein (red) and synaptophysin (green) in primary rat cultures of the myenteric plexus

Group Leaders

Prof. Dr. Thilo Wedel

Director

Otto-Hahn-Platz 8, R.107
Phone: +49 431 880-2489
Telefax: +49 431 880-1557
t.wedel@anat.uni-kiel.de

Scientific Staff

Dr. rer. nat. François Cossais

Otto-Hahn-Platz 8, R. 222
Phone: +49 431 880-3796
Telefax: +49 431 880-1557
f.cossais@anat.uni-kiel.de

Biologist

Dr. rer. nat. Martina Barrenschee

Otto-Hahn-Platz 8, R.127, Haus 2
Phone: +49 431 880-3087
Telefax: +49 431 880-2699
m.barrenschee@anat.uni-kiel.de

Biologist

Priv.-Doz. Dr. rer. nat. Martina Böttner

Otto-Hahn-Platz 8, R.104, Haus 2
Phone: +49 431 880-2430
Telefax: +49 431 880-2699
m.boettner@anat.uni-kiel.de

Biologist

Technical Staff

Frank Lichte

Technical Assistant

Otto-Hahn-Platz 8, R.106a+b
Phone: +49 431 880-3082
Telefax: +49 431 880-1557
f.lichte@anat.uni-kiel.de

Rita Kirsch

Otto-Hahn-Platz 8, R.106a+b
Phone: +49 431 880-3082
Telefax: +49 431 880-1557
r.kirsch@anat.uni-kiel.de

Technical Assistant

Publications

  • Cossais F, Leuschner S, Barrenschee M, Lange C, Ebsen M, Vogel I, Böttner M, Wedel T. Persistent increased enteric glial expression of S100β is associated with low-grade inflammation in patients with diverticular disease. J Clin Gastroenterol 2018; in press
  • Rosenbaum C, Böttner M, Wedel T, Metzger M. Laser-Capture Microdissection for Layer-Specific Analysis of Enteric Ganglia. Methods Mol Biol. 2018;1723:361-369
  • Cossais F, Clawin-Rädecker I, Lorenzen PC, Klempt M. Short Communication: Tryptic β-casein hydrolysate modulates enteric nervous system development in primary culture. J Dairy Sci 2017;100:3396-3403
  • Barrenschee M, Wedel T, Lange C, Hohmeier I, Cossais F, Ebsen M, Vogel I, Böttner M. No neuronal loss, but alterations of the GDNF system in asymptomatic diverticulosis. PLoS One 2017;12
  • Wunsch M, Jabari S, Voussen B, Enders M, Srinivasan S, Cossais F, Wedel T, Boettner M, Schwarz A, Weyer L, Göcer O, Schroeter M, Maeurer M, Woenckhaus M, Pollok K, Radbruch H, Klotz L, Scholz CJ, Nickel J, Friebe A, Addicks K, Ergün S, Lehmann PV, Kuerten S. The enteric nervous system is a potential autoimmune target in multiple sclerosis. Acta Neuropathol 2017;134:281-295
  • Kaiser B, Böttner M, Wedel T, Brunner RM, Goldammer T, Lesko S, Gäbel G, Gleich A, Pfannkuche H. Establishment and Characterization of an SV40 Large T Antigen-Transduced Porcine Colonic Epithelial Cell Line. Cells Tissues Organs. 2017;203:267-286
  • Barrenschee M, Zorenkov D, Böttner M, Lange C, Cossais F, Scharf AB, Deuschl G, Schneider SA, Ellrichmann M, Fritscher-Ravens A, Wedel T. Distinct pattern of enteric phospho-alpha-synuclein aggregates and gene expression profiles in patients with Parkinson's disease. Acta Neuropathol Commun 2017;5
  • Le Berre-Scoul C, Chevalier J, Oleynikova E, Cossais F, Talon S, Neunlist M, Boudin H. A novel enteric neuron-glia coculture system reveals the role of glia in neuronal development. J Physiol 2017;595:583-598
  • Schneider SA, Böttner M, Alexoudi A, Zorenkov D, Deuschl G, Wedel T: Can we use peripheral tissue biopsies to diagnose Parkinson´s disease? A review of the literature. Eur J Neurol 2016;23:247-61
  • Cossais F, Boudaud M, Kermarrec L, Chevalier J, Durand T, Neveu I, Naveilhan and Neunlist M.  Postnatal development of the myenteric glial network and its modulation by butyrate. Am J Physiol Gastrointest Liver Physiol 2016;310,G941-51
  • Wedel T, Barrenschee M, Lange C, Cossais F, Böttner M. Morphologic Basis for Developing Diverticular Disease, Diverticulitis, and Diverticular Bleeding. Viszeralmedizin. 2015;31:76-82
  • Barrenschee M, Böttner M, Harde J, Lange C, Cossais F, Ebsen M, Vogel I, Wedel T: SNAP 25 is abundantly expressed in enteric neuronal networks and upregulated by the neurotrophic factor GDNF. Histochem Cell Biol 2015;143:611-23
  • Böttner M, Fricke T, Müller M, Barrenschee M, Deuschl G, Schneider SA, Egberts JH, Becker T, Fritscher-Ravens A, Ellrichmann M, Schulz-Schaeffer WJ, Wedel T: Alpha-synuclein is associated with the synaptic vesicle apparatus in the human and rat enteric nervous system. Brain Res 2015;21:51-9
  • Wedel T, Barrenschee M, Cossais F, Lange C, Böttner M. Diverticular disease - new insights into pathogenesis. Dtsch Med Wochenschr. 2015;140:1347-52
  • Barrenschee M, Lange C, Cossais F, Egberts JH, Becker T, Wedel T, Böttner M. Expression and function of Neuregulin 1 and its signaling system ERBB2/3 in the enteric nervous system. Front Cell Neurosci. 2015;9:360
  • Hellwig I, Böttner M, Barrenschee M, Harde J, Egberts JH, Becker T, Wedel T: Alterations of the enteric smooth musculature in diverticular disease. J Gastroenterol 2014;49:1241-52
  • Wedel T, Böttner M. Anatomie und Pathogenese der Divertikelkrankheit. Chirurg 2014;85:281-8
  • Böttner M, Ghorbani P, Harde J, Barrenschee M, Hellwig I, Vogel I, Ebsen M, Förster E, Wedel T: Expression and regulation of reelin and its receptors in the enteric nervous system. Mol Cell Neurosci 2014;61:23-33
  • Leifeld L, Germer CT, Böhm S, Dumoulin FL, Häuser W, Kreis M, Labenz J, Lembcke B, Post S, Reinshagen M, Ritz JP, Sauerbruch T, Wedel T, von Rahden B, Kruis W, Kruis W, Germer W: S2k-Leitlinie Divertikelkrankheit/Divertikulitis. Z Gastroenterol 2014;52:663-710
  • Böttner M, Barrenschee M, Hellwig I, Harde J, Egberts JH, Becker T, Zorenkov D, Wedel T. The enteric serotonergic system is altered in patients with diverticular disease. Gut 2013;62:1753-62
  • Fritscher-Ravens A, Milla P, Ellrichmann M, Hellwig I, Böttner M, Hadeler KG, Wedel T. A novel endoscopic prototype device for gastric full-thickness biopsy for the histopathological diagnosis of GI neuromuscular pathology: in vivo porcine long-term survival study (with videos). Gastrointest Endosc 2013;77:262-71
  • Noth R, Häsler R, Stüber E, Ellrichmann M, Schäfer H, Geismann C, Hampe J, Bewig B, Wedel T, Böttner M, Schreiber S, Rosenstiel P, Arlt A. Oral glutamine supplementation improves intestinal permeability dysfunction in a murine acute graft versus host disease model. Am J Physiol Gastrointest Liver Physiol 2013;304:G646-54 
  • Hagl C, Schäfer KH, Hellwig I, Barrenschee M, Harde J, Holtmann M, Porschek S, Egberts JH, Becker T, Wedel T, Böttner M. Expression and function of the Transforming Growth Factor-b system in the human and rat enteric nervous system. Neurogastroenterol Motil 2013;25:601-e464
  • Böttner M, Barrenschee M, Hellwig I, Harde J, Egberts J-H., Becker T, Zorenkov D, Schäfer K-H, Wedel T. The GDNF system is altered in diverticular disease – implications for pathogenesis. PLos One 2013;8:e66290
  • Barrenschee M, Böttner M, Hellwig I, Jonas H, Egberts JH, Becker T, Wedel T. Site-specific gene expression and localization of the growth factor ligand receptors RET, GFRα1 and GFRα2 in the human adult colon. Cell Tissue Res 2013;354:371-80
  • Andresen V, Enck P, Frieling T, Herold A, Ilgenstein P, Jesse N, Karaus M, Kasparek M, Keller J, Kuhlbusch-Zicklam R, Krammer H, Kreis M, Layer P, Madisch A, Matthes H, Mönnikes H, Müller-Lissner S, Preiss J, Sailer M, Schemann M, Schwille-Kiuntke J, Voderholzer W, van der Voort I, Wedel T, Pehl C. S2k-Leitlinie Chronische Obstipation: Definition, Pathophysiologie, Diagnostik und Therapie. Z Gastroenterol. 2013;51:651-72
  • Böttner M, Harde J, Barrenschee M, Hellwig I, Vogel I, Ebsen M, Wedel T. GDNF induces synaptic vesicle markers in enteric neurons. Neurosci Res 2013;77:128-36
  • Wedel T, Barrenschee M, Hellwig I, Harde J, Böttner M (2012) Pathogenesis of diverticulosis and diverticular disease of the colon. Viszeralmedizin 28:164-70
  • Böttner M, Wedel T (2012) Abnormalities of neuromuscular anatomy in diverticular disease. Dig Dis 30:19-23
  • Böttner M, Zorenkov D, Hellwig I, Barrenschee M, Harde J, Fricke T, Deuschl G, Egberts JH, Becker T, Fritscher-Ravens A, Arlt A, Wedel T (2012) Expression pattern and localization of alpha-synuclein in the human enteric nervous system. Neurobiol Dis 48:474-80
  • Böttner M, Barrenschee M, Hellwig I, Harde J, Egberts JH, Becker T, Zorenkov D, Wedel T (2012) The enteric serotonergic system is altered in patients with diverticular disease. Gut 27
  • Pahl R, Brunke G, Steubesand N, Schubert S, Böttner M, Wedel T, Jürgensen C, Hampe J, Schäfer H, Zeissig S, Schreiber S, Rosenstiel P, Reiss K, Arlt A (2011) IL-1β and ADAM17 are central regulators of β-defensin expression in Candida esophagitis. Am J Physiol Gastrointest Liver Physiol 300:G547-53
  • Knowles CH, Veress B, Kapur RP, Wedel T, Farrugia G, Vanderwinden JM, Geboes K, Smith VV, Martin JE, Lindberg G, Milla PJ, De Giorgio R (2011) Quantitation of cellular components of the enteric nervous system in the normal human gastrointestinal tract. Report on behalf of the Gastro 2009 International Working Group. Neurogastroentrol Motil 23:115-24
  • Petto C, Lesko S, Gäbel G, Böttner M, Wedel T, Kacza J, Pfannkuche H (2011) Establishment and characterisation of porcine colonic epithelial cells grown in primary culture. Cells Tissue Organs 194:457-68
  • Keller J, Wedel T, Seidl H, Kreis ME, Andresen V, Preiß JC, Layer P, van der Voort I (2011) S3-Leitlinie der Deutschen Gesellschaft für Verdauungs- und Stoffwechselkrankheiten (DGVS) und der Deutschen Gesellschaft für Neurogastroenterologie und Motilität (DGNM) zu Definition, Pathophysiologie, Diagnostik und Therapie intestinaler Motilitätsstörungen. Z Gastroenterol 49: 374-390
  • Van Landeghem L, Chevalier J, Mahé MM, Wedel T, Urvil P, Derkinderen P, Savidge TC, Neunlist M (2011) Enteric glia promotes intestinal mucosal healing via activation of focal adhesion kinase and release of ProEGF. Am J Physiol Gastrointest Liver Physiol 300:G976-87
  • Zorenkov D, Otto S, Böttner B, Hedderich J, Vollrath O, Peter JP, Buhr H, Wedel T (2011) Morphological alterations of the enteric nervous system in young male patients with rectal prolapse. Int J Colorectal Dis 26:1483-91
  • Böttner M, Bär F, von Koschitzky H, Tafazzoli K, Roblick UJ, Bruch HP, Wedel T (2010) Laser microdissection as a new tool to investigate site-specific gene expression in enteric ganglia of the human intestine. Neurogastroenterol Motil 22:168-72
  • Wedel T, Büsing V, Heinrichs G, Nohroudi K, Bruch HP, Roblick U, Böttner M (2010): Diverticular disease is associated with an enteric neuropathy as revealed by morphometric analysis. Neurogastroenterol Motil 22:407-14
  • Knowles CH, De Giorgio R, Kapur RP, Bruder E, Farrugia G, Geboes K, Lindberg G, Martin JE, Meier-Ruge WA, Milla PJ, Smith VV, Vandervinden JM, Veress B, Wedel T (2010) The London classification of gastrointestinal neuromuscular pathology (GINMP): report on behalf of the Gastro 2009 International Working Group. Gut 59:882-7
  • Teixeira AF, Kühnel W, Vives P, Wedel T (2009). Functional morphology of unguiculiform papillae of the reticular groove in the ruminant stomach. Ann Anat 191:469-76.
  • Knowles CH, De Giorgio R, Farrugia G, Geboes K, Gershon MD, Hutson J, Kapur RP, Lindberg G, Martin JE, Milla PJ, Smith VV, Veress B, Wedel T (2009) Gastrointestinal neuromuscular pathology: guidelines for histological techniques and reporting on behalf of the Gastro 2009 International Working Group. Acta Neuropatho 118:271-301
  • Neunlist M, Coron E, Flamant M, Aubert P, Wedel T, Pedron T, Letessier E, Galmiche JP, Sansonetti PJ (2009) Characterisation of early mucosal and neuronal lesions following Shigella flexneri infection in human colon. PLoS ONE 4(3):e4713
  • Bär F, von Koschitzky H, Roblick U, Bruch HP, Schulze L, Sonnenborn U, Böttner M, Wedel T (2009): Cell-free supernatants of Escherichia coli Nissle 1917 (EcN) modulate human colonic motility - evidence from an in-vitro organ bath study (2009) Neurogastroenterol Motil 21:559-66
  • Wedel T (2007) Functional Anatomy - Prerequisite for the understanding of defecation disorders. Chir Gastroenterol 23: 220-227
  • Wedel T, Böttner M, Krammer HJ (2007) The enteric nervous system and interstitial cells of Cajal. Changes in chronic constipation in adults. Pathologe 28:143-148
  • Hernando-Harder AC, Franke A, Wedel T, Bottner M, Krammer HJ, Singer MV, Harder H (2007) Intestinal Gas Retention in Patients with Idiopathic Slow-Transit Constipation. Dig Dis Sci 52: 2667-75
  • Beutel J, Schroder C, von Hof K, Rades D, Kosmehl H, Wedel T, Sieg P, Geerling G, Hakim S (2007) Pharmacological prevention of radiation-induced dry eye - An experimental study in a rabbit model. Graefes Arch Clin Exp Ophthalmol 245: 1347-55
  • Neunlist M, Aubert P, Bonnaud S, van Landeghem L, Coron E, Wedel T, Naveilhan P, Ruhl A, Lardeux B, Savidge T, Paris F, Galmiche JP (2007) Enteric glia inhibits intestinal epithelial cell proliferation partly through a TGF-ß1-dependent pathway. Am J Physiol Gastrointest Liver Physiol 292: 231-241
  • Kohl M, Wedel T, Entenmann A, Stuttmann J, Bendiks M, Loff S, Koster S, Ortfeld S, Bos I (2007) Influence of different intravenous lipid emulsions on hepatobiliary dysfunction in a rabbit model. J Pediatr Gastroenterol Nutr 44: 237-44
  • Wedel T, van Eys G, Glénisson W, Waltregny D, Vanderwinden JM (2006) Novel smooth muscle markers reveal abnormalities of the intestinal musculature in severe colorectal motility disorders. Neurogastroenterol Motil 18: 526-538
  • Niessen P, Rensen S, van Deursen J, De Man J, De Laet A, Vanderwinden JM, Wedel T, Baker D, Doevendans P, Hofker M, Gijbels M, van Eys G (2005) Smoothelin-A is essential for functional intestinal smooth muscle contractility in mice. Gastroenterology 129: 1592-1601
  • de Lorijn F, de Jonge WJ, Wedel T, Vanderwinden JM, Benninga MA, Boeckxstaens GE (2005) Interstitial cells of Cajal are involved in the afferent limb of the rectoanal inhibitory reflex. Gut 54: 1107-13
  • Tafazzoli K, Soost K, Wessel L, Wedel T (2005) Topographic pecularities of the submucous plexus in the human anorectum - consequences for histopathologic evaluation of rectal biopsies. Eur J Pediatr Surg 15: 159-63
  • Wedel T (2005) Obstipation. Coloproctology 27: 204-208
  • Bruch HP, Schwandner O, Krammer HJ, Söllner S, Wedel T (2004) Ursachen und Therapie des Megakolons beim Erwachsenen. Chir Praxis 62, 605-617
  • Holland-Cunz S, Bainczyk S, Hagl C, Wink E., Wedel T, Back W, Schäfer KH (2004) Three dimensional co-culture model of enterocytes and primary enteric neuronal tissue. Pediatr Surg Internat 20: 233-7
  • Holland-Cunz S, Krammer HJ, Süss A, Tafazzoli K, Wedel T (2003) Molecular genetics of colorectal motility disorders. Eur J Pediatr Surg 13, 146-151
  • Wedel T, Tafazzoli K, Söllner S, Krammer HJ, Holschneider AM (2003) Mitochondrial myopathy (complex I deficiency) associated with chronic intestinal pseudoobstruction. Eur J Pediatr Surg 13, 201-205
  • Krammer HJ, Süss A, Singer MV, Wedel T (2002) Neurogastroenterology - From the Basics to the Clinics. R J Gastroenterology 11, 313-319
  • Wedel T, Spiegler J, Söllner S, Roblick UJ, Schiedeck THK, Bruch HP, Krammer HJ (2002) Interstitial cells of Cajal and the enteric nervous system are concomitantly altered in patients with slow-transit constipation and megacolon. Gastroenterology 123: 1459-1467
  • Von Boyen GBT, Krammer HJ, Dembowski C, Ehrenreich H, Wedel T (2002) Abnormalities of the enteric nervous system in heterozygous endothelin B-receptor deficient (spotting lethal) rats resembling intestinal neuronal dysplasia. Gut 51: 414-419
  • Wedel T, Roblick UJ, Ott V, Eggers R, Schiedeck THK, Krammer HJ, Bruch HP (2002) Oligoneuronal hypoganglionosis in patients with idiopathic slow transit constipation. Dis Colon Rectum 45: 54-62
  • Teixera AF, Krammer HJ, Kühnel W, Wedel T (2001) Structural organisation of the enteric nervous system in the cattle esophagus revealed by wholemount immunohistochemistry. It J Anat Embryol 106: 313-321
  • Böttner M, Krieglstein K, Unsicker K. (2000) The transforming growth factor-betas: structure, signaling, and roles in nervous system development and functions. J Neurochem. 75(6):2227-2240. Review.
  • Wedel T, Spiegler J, Ott V, Kühnel W, Sigge W, Reusche E, Krammer HJ (2000) Intestinale Innervationsstörungen bei chronischer Obstipation. Focus MUL 17: 233-240
  • Wedel T (2000) Mögliche Ursachen der chronischen Obstipation. Zentralbl Chir 125:564-566
  • Wedel T, Roblick UJ, Schiedeck THK, Bruch HP, Reusche E (2000) Erworbene Hypoganglionose als Folge einer enterischen Ganglionitis. Focus MUL 17: 246-248
  • Wedel T, Roblick UJ, Quoß J, Schiedeck THK, Bruch HP, Krammer HJ (1999) Intestinale Innervationsstörungen: Anatomische Grundlagen und Diagnostik. Coloproctology 21: 101-108
  • Wedel T, Eggers R, Gleiß J, Schiedeck THK, Bruch HP, Sigge W, Krammer HJ (1999) Das enterische Nervensystem: Von der Anatomie zur Klinik. Focus MUL 16: 22-30
  • Böttner M, Laaff M, Schechinger B, Rappold G, Unsicker K, Suter-Crazzolara C. (1999) Characterization of the rat, mouse, and human genes of growth/differentiation factor-15/macrophage inhibiting cytokine-1 (GDF-15/MIC-1). Gene. 237(1):105-111.
  • Böttner M, Suter-Crazzolara C, Schober A, Unsicker K. (1999) Expression of a novel member of the TGF-beta superfamily, growth/differentiation factor-15/macrophage-inhibiting cytokine-1 (GDF-15/MIC-1) in adult rat tissues. Cell Tissue Res. 297(1):103-110.
  • Galter D, Böttner M, Krieglstein K, Schomig E, Unsicker K. (1999) Differential regulation of distinct phenotypic features of serotonergic neurons by bone morphogenetic proteins. Eur J Neurosci. 11(7):2444-2452.
  • Galter D, Böttner M, Unsicker K. (1999) Developmental regulation of the serotonergic transmitter phenotype in rostral and caudal raphe neurons by transforming growth factor-betas. J Neurosci Res. 56(5):531-538.
  • Leffler A, Wedel T, Busch LC (1999) Congenital colonic hypoganglionosis in murine trisomy 16 - a model for Down´s syndrome. Eur J Pediatr Surg 9: 381-388
  • Wedel T, Roblick UJ, Schiedeck THK, Bruch HP, Krammer HJ (1999) Ist die Divertikelkrankheit mit intestinalen Innervationsstörungen assoziiert? Viszeralchirurgie 34: 307-311
  • Wedel T, Roblick UJ, Gleiß J, Ott V, Eggers R, Kühnel W, Krammer HJ (1999) Intestinale Innervationsstörungen als mögliche Ursache der chronischen Obstipation. Zentralbl Chir 124: 796-803
  • Wedel T, Roblick UJ, Gleiß J, Schiedeck THK, Bruch HP, Kühnel W, Krammer HJ (1999) Organization of the enteric nervous system in the human colon demonstrated by wholemount immunohistochemistry with special reference to the submucous plexus. Ann Anat 181: 327-337
  • Wedel T, Holschneider AM, Krammer HJ, Kühnel W (1999) Ultrastructural features of nerve fascicles and basal lamina abnormalities in Hirschsprung´s disease. Eur J Ped Surg 9: 75-82
     

Book chapters / Books

  • Wedel T. Anatomische Grundlagen, Pathologie und Pathogenese der Divertikelkrankheit. In Germer C, Leifeld L, Kruis W (eds). Divertikulose und Divertikelkrankheit, Springer, 2017
  • Wedel T, Böttner M. Pathogenese der Divertikelkrankheit. In Kruis W, Leifeld L (eds) Divertikelkrankheit, UNI-MED Verlag, 2015
  • Wedel T, Böttner M. Pathogenesis of diverticular disease. In Kruis W, Leifeld L (eds) Diverticular Disease, UNI-MED Verlag, 2015
  • Wedel T, Krammer HJ (2010) Anatomische und physiologische Grundlagen der gastrointestinalen Motilität. In Buchmann P, Degen L P (eds) Chronische Bauchbeschwerden. Verlag Hans Huber, Bern, Göttingen, Toronto
  • Wedel T, Böttner M (2010) Pathogenese der Divertikelkrankheit. In Kruis W (ed) Divertikelkrankheit. Verlag Uni-Med. Bremen, London, Boston
  • Wedel T, Krammer HJ (2009) Neuroanatomie und Neuropathologie. In Jost W (ed) Neurokoloproktologie - Neurologie des Beckenbodens, 2. Auflage. Verlag Uni-Med. Bremen, London, Boston
  • Wedel T (2009) Ätiologie der chronischen Obstipation. In Krammer HJ, Herold A (ed) Chronische Obstipation in der Praxis und Klinik, Verlag Uni-Med. Bremen, London, Boston
  • Wedel T, Krammer HJ, Holschneider AM (2008) Electron microscopical studies of Hirschsprung´s disease. In Holschneider AM, Puri P (eds) Hirschsprung´s disease and allied disorders. 3. edition. Springer. 
  • Wedel T, Krammer HJ (2005) Neuroanatomie und Physiologie des Kolons. In Jost W (ed) Neurologie des Beckenbodens - Neuroproktologie, 1. Auflage. Verlag Uni-Med. Bremen, London, Boston
  • Wedel T, Krammer HJ (2002) Kolorektale Innervationsstörungen. In Buchmann P (ed) Lehrbuch der Proktologie, 4. Auflage. Verlag Hans Huber. Bern, Göttingen, Toronto, Seattle, pp 180-189
  • Wedel T, Roblick UJ, Schiedeck THK, Schrader S, von Koschitzky H, Bruch HP, Krammer HJ. (2001) Ist die Divertikelkrankheit mit intestinalen Innervationsstörungen assoziiert? In Schumpelick V, Kasperk R (eds) Divertikulitis - Eine Standortbestimmung. Springer. Berlin, Heidelberg, New York, pp 38-43
  • Krammer HJ, Wedel T, Schäfer KH, Schiedeck THK, Roblick UJ, Bruch HP (2001) Intrinsic innervation and innervational abnormalities of the colorectum - from morphology to molecular genetics. In Bruch HP, Frühmorgen P (eds) Non-Neoplastic Diseases of the Anorectum - An Interdisciplinary Approach. Kluwer Academic Publishers. Dordrecht, Boston, London, pp 26-37
  • Krieger F, Wedel T, Meier-Ruge W, Singer MV, Krammer HJ (2000) Immunohistochemical evaluation of the cholinergic, nitrergic and peptidergic innervation of intestinal neuronal dysplasia (IND) in children. The architectural heterogeneity of the enteric nervous system in the forestomach of ruminants. In Krammer HJ, Singer MV (eds) Neurogastroenterology - from the Basics to the Clinics. Kluwer Academic Publishers. Dordrecht, Boston, London, pp 504-510
  • Schneider GBT, Wedel T, Dembowski C, Ehrenreich J, Singer MV, Krammer HJ (2000) Three-dimensional architecture of the enteric nervous system in homozygous endothelin-B-receptor (ETB) deficient (spotting lethal) rats compared to patients with Hirschsprung´s disease. In Krammer HJ, Singer MV (eds) Neurogastroenterology - from the Basics to the Clinics. Kluwer Academic Publishers. Dordrecht, Boston, London, pp 485-492
  • Wedel T, Roblick UJ, Schiedeck THK, Bruch HP, Krammer HJ (2000) The enteric nervous system of the human colon demonstrated by wholemount immunohistochemistry: normal structure and histopathlogy in chronic intestinal motility disorders. In Krammer HJ, Singer MV (eds) Neurogastroenterology - from the Basics to the Clinics. Kluwer Academic Publishers. Dordrecht, Boston, London, pp 441-453
  • Teixeira AF, Wedel T, Kühnel W, Krammer HJ (2000) The architectural heterogeneity of the enteric nervous system in the forestomach of ruminants. In Krammer HJ, Singer MV (eds) Neurogastroenterology - from the Basics to the Clinics. Kluwer Academic Publishers. Dordrecht, Boston, London, pp 107-115
  • Leffler A, Wedel T, Busch LC (2000) Abnormalities of the enteric nervous system in an animal model for Down´s Syndrome. In Krammer HJ, Singer MV (eds) Neurogastroenterology - from the Basics to the Clinics. Kluwer Academic Publishers. Dordrecht, Boston, London, pp 496-503
  • Wedel T, Krammer HJ, Holschneider AM (2000) Electron microscopical studies of Hirschsprung´s disease. In Holschneider AM, Puri P (eds) Hirschsprung´s disease and allied disorders. Harwood Academic Publishers. Amsterdam, pp 280-290 
  • Krammer HJ, Wedel T, Singer MV (1999) Kolorektale Innervation und Innervationsstörungen - von der Morphologie zur Molekulargenetik. In Kirchner T, Lembcke B, Kist M (eds) Ökosystem Darm VIII. Springer. Berlin, pp 215-232
  • Krammer HJ, Wedel T, Krieger F, Wessel L, Meier-Ruge W, Singer MV (1998) Evaluation of the intrinsic nervous system in human colonic biopsies by immunohistochemistry for neuronal and glial proteins. In Holtmann G, Goebell H, Talley NJ (eds) Functional and irritable bowel syndrom: Concepts and controversies. Kluwer Academic Publishers. Dordrecht, Boston, Londen, pp 60-66
  • Freund U, Krammer HJ, Sigge W, Wedel T, Kühnel W (1995) Nerves and endocrine cells in the neomucosa. In Singer MV, Ziegler R, Rohr G (eds) Gastrointestinal Tract and Endocrine System. Kluwer Academic Publishers. Dordrecht, Boston, London, pp 89-92