Research Group Hattermann/Mentlein

Group Leaders

Dr. rer. nat. Kirsten Hattermann-Koch

Otto-Hahn-Platz 8, R. 227
Phone: +49 431 880-2460
Telefax: +49 431 880-1557


Technical Staff

Judith Becker

Technical Assistant

Otto-Hahn-Platz 8, R. 225
Phone: +49 431 880-7294
Telefax: +49 431 880-1557

Sonja Dahle

Technical Assistant

Otto-Hahn-Platz 8, R. 207
Phone: +49 431 880-2468
Telefax: +49 431 880-1557


Role of chemokines, growth and angiogenic factors in the proliferation, spreading and metastasis of tumours

Chemokines are a group of small chemotactic peptides that play an essential role not only in the migration cells, but also for their survival and proliferation. They were originally discovered as chemotactic factors in the immune system, but they have a much broader function in development, e. g. in the brain, and also in may pathological conditions. We are investigating the role of chemokines and other bioactive peptides in tumours, in particular their influence on tumour growth, spreading and invasion. Focus is laid on brain tumours (especially gliomas which show a very high mortality) and the metastasis of peripheral tumours (melanoma, mamma carcinoma) into the brain.


  • Scientists involved: Dr. Kirstin Hattermann; Dipl.-Biochem. Henrike Gebhardt; cand. med. Sara Ardabili, cand. med. Dorothee Engel, cand. med. dent. Eric Holzenburg, cand. med. Max Lempert, cand. med. dent. Gunnar Meyer, cand. med. dent. Alina Schroeter; Martina Burmester, Sonja Dahle, Miriam Lemmer
  • Cooperation with Prof. Dr. Dr. Janka Held-Feindt, PD Dr. Friedrike Knerlich-Lukoschus Prof. Dr. H. M. Mehdorn (Klinik für Neurochirurgie, Kiel), Prof. Dr. Ralph Lucius (Anatomisches Institut, Universität Kiel), Prof. Dr. Karina Reiß (Klinik für Dermatologie, Universität Kiel), Prof. Dr. Christian Peifer (Pharmazeutische Chemie, Universität Kiel); - Prof. Dr. Uwe Knippschild (Universität Ulm, Klinik für Allgemein- und Viszeralchirurgie); Prof. Dr. Andreas Ludwig (RWTH Technische Hochschule Aachen, Institut für Pharmakologie und Toxikologie); Prof. Dr. Friedrich Paulsen (Friedrich-Alexander-Universität Erlangen-Nürnberg, Anatomie, Erlangen); PD Dr. Margret Schottelius und Prof. Dr. Hans-Jürgen Wester (Technische Universität München, Pharmazeutische Radiochemie); Prof. Dr. Udo Schumacher (Universität Hamburg; Anatomie)
  • Grants: Excellence cluster »Inflammation at interfaces«, Medical faculty of the University of Kiel, Deutsche Forschungsgemeinschaft DFG ME 758/10-1


Molecular Imaging
Sensitive imaging of pathological alterations in vivo, in particular the detection of cancer, requires the development of novel contrast agents. We currently develop novel supraparamagnetic or near-infrared fluorescent conjugates for the sensitive MRI or optical detection of very small tumours and their metastases.

  • Scientists involved: Martina Burmester, Miriam Lemmer, Judith Becker
  • Cooperation with Prof. Dr. Claus-C. Glüer, Prof. Dr. Martin Heller (Klinik für Diagnostische Radiologie, Medizinische Physik), Prof. Dr. Holger Kalthoff, Dr. Sanjay Tiwari (Molekulare Onkologie), Prof. Dr. Olav Jansen, Dr. Monika Huhndorf (Neuroradiologie)
  • Grants: MOIN (Molecular Imaging in the North) - Ministerium für Wirtschaft, Arbeit, Verkehr und Technologie S.-H.


Chemokines in osteoporosis and bone fractures
Osteoporosis and resulting bone fractures are increasing problems in an elderly society. Since chemokines are not only involved in inflammation, but play a decisive role in development and tissue homeostasis, we investigate their role in the muscular-skeletal system. First studies reveal a particular role of the chemokine CXCL12/SDF-1 and its receptors CXCR4 and CXCR7 in the development of murine and human bones. Therefore, ongoing in vitro and in vivo studies focus on the role of this system in osteoporosis and bone fracture healing.

  • Scientists involved: Tim Klüter
  • Cooperation with: PD. Dr. Deike Varoga, Prof. Dr. Andreas Seekamp, Dr. Stefanie Oestern (Department of Trauma Surgery, University Medical Center of Schleswig-Holstein, Campus Kiel, Germany)

Technologies & Methods

  • Molecular biology: Real time RT-PCR, Northern Blots, cell transfections, cloning, site-directed mutagenesis, S1- and S2 laboratories
  • Biochemistry, peptide- and protein separations including HPLC, FPLC
  • Electrophoresis, immuno blots, electrophoretic mobility shift assays, ELISA, RIA, enzyme assays, radioactive labeling
  • Cell culture: astroglia, microglia, neural stem cells, tumuor cells, tumour stem-like cells, endothelial cells
  • Cell biology: proliferation assays, migration/invasion assays, immuno histo/cyto-chemistry, immuno electron microscopy



  • Hattermann K, Knerlich-Lukoschus F, Lucius R, Mehdorn M, Held-Feindt J. (2015) Erythropoietin and CCL3 antagonise their functional properties during neuroinflammation. Neurol. Res. 37, 1025-1028.
  • Krossa S, Schmitt AD, Hattermann K, Fritsch J, Scheidig AJ, Mehdorn HM, Held-Feindt J. (2015) Down regulation of Akirin-2 increases chemosensitivity in human glioblastomas more efficiently than Twist-1. Oncotarget 6, 21029-21045.
  • Kubelt C, Hattermann K, Sebens S, Mehdorn HM, Held-Feindt J. (2015) Epithelial-to-mesenchymal transition in paired human primary and recurrent glioblastomas. Int. J. Oncol. 46, 2515-2525.
  • Stark AM, Doukas A, Hugo HH, Hedderich J, Hattermann K, Maximilian Mehdorn H, Held-Feindt J.(2015) Expression of DNA mismatch repair proteins MLH1, MSH2, and MSH6 in recurrent glioblastoma. Neurol. Res. 37, 95-105.


  • Sedo A, Mentlein R (2014) Glioma Cell Biology (eds.; 468 p, 56 illus., 52 illus. in color), Springer Science+Business Media: Dordrecht - Heidelberg – New York - London, ISBN 978-3-7091-1431-5 (eBook), ISBN 978-3-7091-1430-8 (Hardcover).
  • Hattermann K, Mentlein R (2014) Para- and autocrine mediators in the glioma microenvironment. In: Glioma Cell Biology (Sedo A, Mentlein R, eds.) Springer Science+Business Media: Dordrecht - Heidelberg – New York - London, ISBN 978-3-7091-1431-5 (eBook), ISBN 978-3-7091-1430-8 (Hardcover).
  • Hettich C, Wilker S, Mentlein R, Lucius R, Roider J, Klettner A. (2014) The retinal pigment epithelium (RPE) induces FasL and reduces iNOS and Cox2 in primary monocytes. Graefes Arch. Clin. Exp. Ophthalmol. Graefes Arch Clin Exp Ophthalmol 252, 1747-1754.
  • Klüter T, Fitschen-Oestern S, Lippross S, Weuster M, Mentlein R, Steubesand N, Neunaber C, Hildebrand F, Pufe T, Tohidnezhad M, Beyer A, Seekamp A, Varoga D (2014) The antimicrobial peptide lysozyme is induced after multiple trauma. Mediators Inflamm. 2014, 303106.
  • Hattermann K, Holzenburg E, Hans F, Lucius R, Held-Feindt J, Mentlein R (2014). Effects of the chemokine CXCL12 and combined internalization of its receptors CXCR4 and CXCR7 in human MCF-7 breast cancer cells. Cell Tissue Res 357, 253-266.
  • Hattermann K, Sebens S, Helm O, Schmitt AD, Mentlein R, Mehdorn HM, Held-Feindt J (2014). Chemokine expression profile of freshly isolated human glioblastoma-associated macrophages/microglia. Oncol Report 32, 270-276.


  • Hattermann K, Held-Feindt J, Ludwig A, Mentlein R. The CXCL16–CXCR6 chemokine axis in glial tumors. J. Neuroimmunol. 260, 47–54.
  • Mentlein R, Hattermann K, Held-Feindt J. Migration, metastasis and more: The role of chemokines in the proliferation, spreading and metastasis of tumors. In: Resende R, Ulrich H (eds). Trends in Stem Cells Proliferation and Cancer Research, Springer-Verlag: Wien-New York,  pp. 339-358. ISBN 978-94-007-6210-7
  • Hattermann K, Mentlein R, Mehdorn HM, Held-Feindt J. Expression of the chemokines CXCL12 and CX3CL1 and their receptors in human nerve sheath tumors. Histol. Histopathol. 28, 1337-49.
  • Hattermann K, Mentlein R. An Infernal Trio: The chemokine CXCL12 and its receptors CXCR4 and CXCR7 in tumor biology. Ann. Anat. 195: 103-10, 2013.
  • Li G, Hattermann K, Mentlein R, Mehdorn HM, Held-Feindt J. The transmembrane chemokines CXCL16 and CX3CL1 and their receptors are expressed in human meningiomas. Oncology Reports 29: 563-70, 3013.
  • Held-Feindt J, Hattermann K, Sebens S, Krautwald S, Mehdorn HM, Mentlein R. The transcription factor Forkhead box P3 (FoxP3) is expressed in glioma cells and associated with increased apoptosis. Exp. Cell Res. 319: 731-9, 2013.


  • Held-Feindt J, Schmelz S, Hattermann K, Mentlein R, Mehdorn HM, Sebens S. The neural adhesion molecule L1CAM confers chemoresistance in human glioblastomas. Neurochem. Int. Neurochem Int. 61:1183-91, 2012.
  • Hattermann K, Mentlein R, Held-Feindt J. CXCL12 mediates apoptosis resistance in rat C6 glioma cells. Oncology Reports 27:1348-52, 2012.
  • Mentlein R, Hattermann K, Held-Feindt J. Lost in disruption: Role of proteases in glioma invasion and progression. Biochim Biophys Acta - Rev. Cancer 825:178-85, 2012.
  • Odemis V, Lipfert J, Kraft R, Hajek P, Abraham G, Hattermann K, Mentlein R, Engele J. The presumed atypical chemokine receptor CXCR7 signals through G(i/o) proteins in primary rodent astrocytes and human glioma cells. Glia 60:372-81, 2012.
  • Lippross S, Klueter T, Steubesand N, Oestern S, Mentlein R, Hildebrandt F, Podschun R, Pufe T, Seekamp A, Varoga D. Multiple trauma induces serum production of host defence peptides. Injury, Int. J. Care Injured 43:137-42, 2012.


  • Meincke M, Tiwari S, Hattermann K, Kalthoff H, Mentlein R. Near-infrared molecular imaging of tumors via chemokine receptors CXCR4 and CXCR7. Clin Exp Metastasis 28: 713-20, 2011.
  • Hattermann K, Held-Feindt J, Mentlein R. Spheroid confrontation assay: A simple method to monitor the three-dimensional migration of different cell types in vitro. Ann Anat 193:181-184, 2011.
  • Mentlein R, Hattermann K, Hemion C, Jungbluth A, Held-Feindt J. Expression and role of the cell surface protease seprase/fibroblast activation protein-α (FAP-α) in astroglial tumors. Biol Chem 392, 199-207, 2011.
  • Held-Feindt J, Hattermann K, Knerlich-Lukoschus F, Mehdorn HM, Mentlein R. SP100 reduces malignancy of human glioma cells. Int J Oncol 38: 1023-30, 2011.
  • Schlorf T, Meincke M, Kossel E, Glüer CC, Jansen O, Mentlein R. Biological properties of iron oxide nanoparticles for cellular and molecular magnetic resonance imaging. Int J Mol Sci 12: 12-23, 2011


  • Hattermann K, Held-Feindt J, Lucius R, Sebens Müerköster S, Penfold M E T, Schall T J, Mentlein R. The chemokine receptor CXCR7 is highly expressed in human glioma cells and mediates anti-apoptotic effects. Cancer Res 70: 3299-308, 2010.
  • Held-Feindt J, Hattermann K, Müerköster SS, Wedderkopp H, Knerlich-Lukoschus F, Ungefroren H, Mehdorn HM, Mentlein R. CX3CR1 promotes recruitment of human glioma-infiltrating microglia/macrophages (GIMs). Exp Cell Res 16: 1553-66, 2010.
  • Lettau I, Hattermann K, Held-Feindt J, Brauer R, Sedlacek R, Mentlein R. Matrix Metalloproteinase-19 is Highly Expressed in Astroglial Tumors and Promotes Invasion of Glioma Cells. J Neuropathol Exp Neurol 69:215-23, 2010.
  • Lemke AK, Sandy JD, Voigt H, Dreier R, Lee JH, Grodzinsky AJ, Mentlein R, Fay J, Schünke M, Kurz B. Interleukin-1α treatment of meniscal explants stimulates the production and release of aggrecanase-generated, GAG-substituted aggrecan products and also the release of pre-formed, aggrecanase-generated G1 and m-calpain-generated G1-G2. Cell Tissue Res 340:179-88, 2010.
  • Akay I, Oxmann D, Helfenstein A, Mentlein R, Schünke M, Hassenpflug J, Kurz B. Tumor risk by tissue engineering: cartilaginous differentiation of mesenchymal stem cells reduces tumor growth. Osteoarthritis Cartilage 18:389-96, 2010.
  • Lee SB, Schramme A, Doberstein K, Dummer R, Abdel-Bakky MS, Keller S, Altevogt P, Oh ST, Reichrath J, Oxmann D, Pfeilschifter J, Mihic-Probst D, Gutwein P. ADAM10 Is Upregulated in Melanoma Metastasis Compared with Primary Melanoma. J Invest Dermatol 130: 763-73, 2010.
  • Lee SB, Schramme A, Doberstein K, Dummer R, Abdel-Bakky MS, Keller S, Altevogt P, Oh ST, Reichrath J, Oxmann D, Pfeilschifter J, Mihic-Probst D, Gutwein P. ADAM10 Is Upregulated in Melanoma Metastasis Compared with Primary Melanoma. J Invest Dermatol 130: 763-73, 2010.


  • Kranich S, Hattermann K, Specht A, Lucius R, Mentlein R. VEGFR-3/Flt-4 mediates proliferation and chemotaxis in glial precursor cells. Neurochem Int 55: 747-753, 2009.
  • Voigt H, Lemke AK, Mentlein R, Schünke M, Kurz B. Tumor necrosis factor alpha-dependent aggrecan cleavage and release of glycosaminoglycans in the meniscus is mediated by nitrous oxide-independent aggrecanase activity in vitro. Arthritis Res Ther 11: R141, 2009.
  • Mentlein R. Mechanisms underlying the rapid degradation and elimination of the incretin hormones GLP-1 and GIP. Best Pract Res Clin Endocrinol Metab 23: 443-452, 2009.
  • Minsel I, Mentlein R, Sel S, Diebold Y, Bräuer L, Mühlbauer E, Paulsen FP. Somatostatin actions via somatostatin receptors on the ocular surface are modulated by inflammatory processes. Endocrinology 150: 2254-2263, 2009.
  • Varoga D, Wruck CJ, Tohidnezhad M, Brandenburg L, Paulsen F, Mentlein R, Seekamp A, Besch L, Pufe T. Osteoblasts participate in the innate immunity of the bone by producing human beta defensin-3. Histochem Cell Biol 131: 207-18, 2009.


  • Varoga D, Tohidnezhad M, Paulsen F, Wruck CJ, Brandenburg L, Mentlein R, Lippross S, Hassenpflug J, Besch L, Müller M, Jürgens C, Seekamp A, Schmitt L, Pufe T. The role of human beta-defensin-2 in bone. J Anat 213: 749-757, 2008.
  • Hattermann K, Ludwig A, Gieselmann V, Held-Feindt J, Mentlein R. The chemokine CXCL16 induces migration and invasion of glial precursor cells via its receptor CXCR6. Mol Cell Neuroscience 39: 133-141,2008.
  • Ludwig A, Mentlein R. Gial cross-talk by transmemberane chemokines CX3CL1 and CXCL16. J. Neuroimmunol 198: 92-97, 2008.
  • Beck IM, Rückert R, Brandt K, Mueller MS, Sadowski T, Brauer R, Schirmacher P, Mentlein R, Sedlacek R. MMP19 is essential for T cell development and T cell-mediated cutaneous immune responses. PLOS One 3: e2343 (1-11), 2008.
  • Meincke M, Schlorf T, Kossel E Jansen O, Glüer C-C, Mentlein R. Iron oxide - loaded liposomes for MR imaging. Frontiers Bioscience 13: 4002-4008, 2008.
  • Hattermann K, Mehdorn HM, Mentlein R, Schultka S, Held-Feindt J. A methylation-specific and SYBER®-Green-based quantitative PCR technique for MGMT promoter methylation analysis. Anal Biochem 377: 62-71, 2008.
  • Held-Feindt J, Rehmke B, Mentlein R, Hattermann K, Knerlich F, Hugo H-H, Ludwig A, Mehdorn HM. Overexpression of CXCL16 and its receptor CXCR6/Bonzo promotes growth of human schwannomas. Glia 56: 764-774, 2008.
  • Oxman D, Held-Feindt J, Stark AM, Hattermann K, Yoneda T, Mentlein R. Endoglin expression in metastatic breast cancer cells enhances their invasive phenotype. Oncogene 27: 3567-3575. 2008.
  • Pufe T, Petersen W, Fändrich F, Varoga D, Wruck CJ, Mentlein R, Helfenstein A, Hoseas D, Dressel S, Tillmann B, Ruhnke M. Programmable cells of monocytic origin (PCMO): a source of peripheral blood stem cells that generate collagen type II-producing chondrocytes. J Orthop Res 26: 304-13, 2008.
  • Ma Y, Mentlein R, Kruse ML, Knerlich F, Mehdorn HM, Held-Feindt J. Expression of tumor stem cell markers in astrocytomas of different WHO grades. J Neuro-Oncol 86: 31-45, 2008.


  • Beck IM, Müller M, Mentlein R, Sadowski T, Mueller MS, Paus R, Sedlacek R. Matrix metalloproteinase-19 expression in keratinocytes is repressed by transcription factors Tst-1 and Skn-1a: implications for keratinocyte differentiation. J Invest Dermatol 127: 1107-14, 2007.
  • Tong Y, Mentlein R, Buhl R, Hugo H-H, Mehdorn HM, Held-Feindt J. Overexpression of midkine contributes to anti-apoptotic effects in human meningiomas. J Neurochem 100: 1097-1107, 2007
  • Stark AM, Anuszkiewicz B, Mentlein R, Yoneda T, Mehdorn HM, Held-Feindt J. Differential expression of matrix metalloproteinases in brain- and bone-seeking clones of metastatic MDA-MB-231 breast cancer cells. J Neuro-Oncol 81: 39-48, 2007.
  • Pufe T, Groth G, Goldring MB, Tillmann B, Mentlein R. Effects of pleiotrophin, a heparin-binding growth factor, on human primary and immortalized chondrocytes. Osteoarthritis Cartilage 15: 155-62, 2007.
  • Koch, M., May, U., Kuhns, S., Drechsler, H., Adam, N., Hattermann, K., Wirtz, S., Rose-John, S., and Scheller, J. Interleukin 27 induces differentiation of neural C6-precursor cells into astrocytes. Biochem Biophys Res Commun. 364: 483-7, 2007.
  • Mentlein, R. Targeting pleiotrophin to treat osteoarthritis. Expert Opinion on Therapeutic Targets 11: 861-867, 2007.


  • Varoga, D., Paulsen, F., Mentlein, R., Fay, J., Kurz, B., Schutz, R., Wruck, C., Goldring, M., and Pufe, T. (2006). TLR-2-mediated induction of vascular endothelial growth factor (VEGF) in cartilage in septic joint disease. J. Pathol. 210, 315-324.
  • Held-Feindt, J., Dörner, L., Gülcan, S., Mehdorn, H. M., and Mentlein, R. (2006). Cannabinoid receptors in human gliomas. J. Neurochem. 98, 886-893.
  • Schindler, R., and Mentlein, R. (2006) Flavonoids and vitamin E reduce the release of the angiogenic peptide vascular endothelial growth factor from human tumor cells. J. Nutrition 136, 1477-1482.
  • Mentlein, R., Stec, I., und Wiegers G. J. (2006). Immunologie des Thymus und Einflüsse des Nervensystems und der Glucokortikoide. In: "Lehrbuch der klinischen Pathophysiologie komplexer chronischer Erkrankungen. Band 1, Physiologische Grundlagen" (R. H. Straub, Ed.), S. 119-129. Vandenhoeck & Ruprecht, Göttingen.
  • Varoga, D., Paulsen, F. P., Kohrs, S., Grohmann, S., Lippross, S., Mentlein, R., Tillmann, B. N., Goldring, M. B., Besch, L., and Pufe, T. (2006). Expression and regulation of human beta-defensin 2 in osteoarthritic cartilage. J. Pathol. 209, 166-173.
  • Held-Feindt, J., Bernedo Paredes, E., Blömer, U., Seidenbecher, C., Stark, A. M., Mehdorn, H. M., and Mentlein, R. (2006). The matrix-degrading proteases ADAMTS4 and ADAMTS5 (disintegrins and metalloproteinases with thrombospondin motifs 4 and 5) are expressed in human glioblastomas. Int. J. Cancer 118, 55-61.


  • Mentlein, R. (2005). Dipeptidyl-peptidase IV and aminopeptidase P: molecular switches of NPY/PYY receptor affinities. In: "The NPY Family of Peptides in Immune Disorders, Inflammation, Angiogenesis and Cancer" (Z. Zukowska, G. Z. Feuerstein, Eds.). Birkhäuser-Verlag, Basel, pp. 75-84.
  • Varoga, D., Pufe, T., Mentlein, R., Kohrs, S., Grohmann, S., Tillmann, B., Hassenpflug, J., and Paulsen, F. (2005). Expression and regulation of antimicrobial peptides in articular joints. Ann. Anat. 187, 499-508.
  • Pufe, T., Kurz, B., Petersen, W., Varoga, D., Mentlein, R., Kulow, S., Lemke, A., and Tillmann, B. (2005). The influence of biomechanical parameters on the expression of VEGF and endostatin in the bone and joint system. Ann. Anat. 187, 461-72.
  • Pufe, T., Petersen, W., Mentlein, R., and Tillmann, B. (2005). The role of vasculature and angiogenesis for the pathogenesis of degenerative tendons disease. Scand. J. Med. Sci. Sports 15, 211-22.
  • Ludwig, A., Schulte, A., Schnack, C., Hundhausen, C., Reiss, K., Brodway, N., Held-Feindt, J., and Mentlein, R. (2005). Enhanced expression and shedding of the transmembrane chemokine CXCL16 by reactive astrocytes and glioma cells. J. Neurochem. 93, 1293-1303.
  • Varoga, D., Pufe, T., Harder, J., Schröder, J.-M., Mentlein, R., Meyer-Hoffert, U., Goldring, M. B., Tillmann, B., and Paulsen, F. (2005). Human ?-defensin-3 mediates tissue remodelling processes in articular cartilage by increasing metalloproteinases and reducing their endogenous inhibitors. Arthritis Rheumatism 52, 1736-1745.
  • Huang, H., Held-Feindt, J., Buhl, R., Mehdorn, H. M., Mentlein, R. (2005). Expression of VEGF and its receptors in different brain tumors. Neurological Res. 27, 371-377.
  • Gebhardt, M., Mentlein, R., Schaudig, U., Pufe, T., Recker, K., Nolle, B., Al-Samir, K., Geerling, G., and Paulsen, F.P. (2005). Differential expression of vascular endothelial growth factor implies the limbal origin of pterygia. Ophthalmology 112, 1023-1030.
  • Mest, H.-J., and Mentlein, R. (2005). Dipeptidyl peptidase inhibitors as new drugs for the treatment of type 2 diabetes. Diabetologia 48, 616-620.
  • Mentlein, R. (2005). Therapeutic assessment of glucagon-like peptide-1 agonists compared with dipeptidyl peptidase IV inhibitors as potential antidiabetic drugs. Expert Opin. Invest. Drugs 14, 57-64.
  • Mentlein, R., and Pufe, T. (2005). New functions of angiogenic peptides in osteoarthritic cartilage. Current Rheumatology Reviews 1, 37-43.


  • Varoga, D., Pufe, T., Harder, J., Meyer-Hoffert, U., Mentlein, R., Schröder, J.-M., Petersen, W. J., Tillmann, B. N., Proksch, E., Goldring, M. B., and Paulsen, F. P. (2004). Production of endogenous antibiotics in articular cartilage. Arthritis Rheumatism 50, 3526-3534
  • Schneider-Brachert W, Tchikov V, Winoto-Morbach S, Neumeyer J, Jakob M, Held-Feindt J, Heinrich M, Merkel O, Ehrenschwender M, Adam D, Mentlein R, Kabelitz D, Schütze S (2004). Compartmentalization of TNF-Receptor-1 Signaling: Internalized TNF-Receptosomes as Death Signaling Vesicles. Immunity 21, 415-428.
  • Pufe T, Petersen W J, Miosge N, Goldring M B, Mentlein R, Varoga D J, Tillmann B N (2004). Endostatin / collagen XVIII - an inhibitor of angiogenesis - is expressed in cartilage and fibrocartilage. Matrix Biology 23, 267-276.
  • Becker, R., Pufe, T., Kulow, S., Giessmann, N., Neumann, W., Mentlein, R., and Petersen, W. (2004). Expression of vascular endothelial growth factor during healing of the meniscus in a rabbit model. J. Bone Joint Surgery (British) 86, 1082-1087.
  • Pufe, T., Mentlein, R., Tsokos, M., Steven, P., Varoga, D., Goldring, M.B., Tillmann, B. N., and Paulsen, F. P. (2004). VEGF expression in adult permanent thyroid cartilage: Implications for lack of cartilage. Bone 35, 543-552.
  • Mentlein R (2004). Cell surface peptidases. Int. Rev. Cytology 235, 165-213.
  • Abel S, Hundhausen C, Mentlein R, Schulte A, Berkhout T A, Broadway N, Hartmann D, Sedlacek R, Dietrich S, Muetze B, Schuster B, Kallen K-J, Saftig P, Rose-John S, Ludwig A (2004). The transmembrane CXC-chemokine ligand 16 is induced by IFN-? and TNF-a and shed by the activity of the disintegrin-like metalloproteinase ADAM10. J. Immunol. 172, 6362-6372.
  • Mentlein R, Forstreuter F, Mehdorn H M, Held-Feindt J (2004). Functional significance of vascular endothelial growth factor receptor expression on human glioma cells. J. Neuro-Oncology 67, 9-18.
  • Petersen, W., Varoga, D., Zantop, T., Hassenpflug, J., Mentlein, R., and Pufe, T. (2004). Cyclic strain influences the expression of the vascular endothelial growth factor (VEGF) and the hypoxia inducible factor 1 alpha (HIF-1alpha) in tendon fibroblasts. J. Orthop. Res. 22, 847-853.
  • Pufe T, Harde V, Petersen W, Goldring M B, Tillmann B, Mentlein R (2004). Vascular endothelial growth factor (VEGF) induces matrix metalloproteinase expression in immortalized chondrocytes, J. Pathol. 202, 367-374.
  • Petersen W, Pufe T, Zantop T, Tillmann, B, Tsokos M, Mentlein R (2004) Expression of VEGFR-1 and VEGFR-2 in degenerative Achilles tendons. Clin. Orthop. 420, 286-291.
  • Pufe T, Lemke A, Kurz B, Petersen W, Tillmann B, and Mentlein R (2004) Mechanical overload induces VEGF in cartilage discs via hypoxia-inducible factor (HIF). Amer. J. Pathol. 164, 185-192.